The Hume Center is a department within Virginia Tech and administratively organized under the Office of the Vice President for Research and Innovation as a University Center. Center governance is provided by its stakeholders board.  In addition to the stakeholders board, an external advisory board provides strategic guidance to the Center. Members of this advisory board are national security leaders who seek to ensure the original vision of Ted and Karyn Hume are preserved in the programs undertaken by the Hume Center.

The Hume Center is broken down into individual laboratories that each execute programs in their respective area. See the diagram below for more detail.